Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543937 | 0.97 | MEN1 (0.39) | MEN1KMT2ASLC6A3OPRK1KDM4E | |
| SCHEMBL7761430 | 0.88 | MEN1 (0.41) | MEN1KMT2ASLC6A3KDM4EALDH1A1 | |
| SCHEMBL8125379 | 0.85 | MEN1 (0.44) | MEN1KMT2ASLC6A3ALDH1A1 | |
| SCHEMBL8485274 | 0.84 | MEN1 (0.36) | MEN1KMT2ASLC6A3OPRK1KDM4E | |
| SCHEMBL6543753 | 0.82 | MEN1 (0.38) | MEN1KMT2ASLC6A3OPRK1KDM4E | |
| SCHEMBL4630796 | 0.81 | MEN1 (0.37) | MEN1KMT2ASLC6A3SMN1; SMN2SLC6A4 | |
| SCHEMBL6952332 | 0.80 | SLC6A3 (0.36) | MEN1KMT2ASLC6A3OPRK1KDM4E | |
| SCHEMBL4631276 | 0.80 | MEN1 (0.40) | MEN1KMT2ASLC6A3P2RX3 | |
| SCHEMBL8484373 | 0.79 | MEN1 (0.38) | MEN1KMT2ASLC6A3OPRK1KDM4E | |
| SCHEMBL6947257 | 0.77 | SLC6A3 (0.37) | MEN1KMT2ASLC6A3OPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859029-A | TREATING SUBSTANCE P-DEPENDENT PATHOLOGICAL CONDITIONS | SANOFI (FR) | 1999-01-12 | — | — | US | disclosed |
| US-5656639-A | POSSESS STRONG AFFINITY FOR NK1 RECEPTORS; USEFUL IN TREATMENT OF SUBSTANCE P-DEPENDENT PATHOLOGICAL CONDITIONS | SANOFI (FR) | 1997-08-12 | — | — | US | disclosed |