SCHEMBL8479554

SCHEMBL8479554

COc1ccc(Cl)cc1-c1c(NCc2ccco2)c(=O)[nH]c2ccc(C(F)(F)F)cc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 6/20 0.59
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
KDM4E B2RXH2 4/20 0.41
TSHR P16473 3/20 0.41
HSD17B10 Q99714 3/20 0.41
MAPT P10636 3/20 0.41
ALOX15 P16050 2/20 0.41
USP2 O75604 2/20 0.41
MAPK1 P28482 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
RAB9A P51151 3/20 0.40
NPC1 O15118 2/20 0.40
HPGD P15428 5/20 0.39
ALDH1A1 P00352 4/20 0.39
GAA P10253 1/20 0.39
CTNNB1 P35222 1/20 0.39
TCF7L2 Q9NQB0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8479277 0.86 CYP2C9 (0.62) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8477410 0.85 CYP2C9 (0.55) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8476301 0.84 CYP2C9 (0.61) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8482093 0.84 CYP2C9 (0.61) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8476431 0.83 CYP2C9 (0.59) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8481775 0.83 CYP2C9 (0.60) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8481581 0.83 CYP2C9 (0.60) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8482038 0.82 CYP2C9 (0.68) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8479050 0.82 CYP2C9 (0.57) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8480443 0.82 CYP2C9 (0.59) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972961-A ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-10-26 US disclosed