SCHEMBL8480443

SCHEMBL8480443

COc1ccc(Cl)cc1-c1c(NCc2ccsc2)c(=O)[nH]c2ccc(C(F)(F)F)cc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 6/20 0.59
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
PDE5A O76074 4/20 0.40
IDH1 O75874 1/20 0.38
PDE6D O43924 1/20 0.37
PDE6A P16499 1/20 0.37
PDE6G P18545 1/20 0.37
PDE6B P35913 1/20 0.37
PDE6C P51160 1/20 0.37
PDE6H Q13956 1/20 0.37
CNR1 P21554 1/20 0.36
MAP2 P11137 1/20 0.36
KCNQ3 O43525 1/20 0.35
KCNQ2 O43526 1/20 0.35
KCNQ4 P56696 1/20 0.35
KCNMA1 Q12791 1/20 0.35
KCNQ5 Q9NR82 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8479277 0.88 CYP2C9 (0.62) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8476301 0.87 CYP2C9 (0.61) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8482093 0.87 CYP2C9 (0.61) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8481581 0.86 CYP2C9 (0.60) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8481775 0.86 CYP2C9 (0.60) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8481578 0.84 CYP2C9 (0.58) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8479050 0.84 CYP2C9 (0.57) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8482038 0.82 CYP2C9 (0.68) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8476431 0.82 CYP2C9 (0.59) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL8479554 0.82 CYP2C9 (0.59) CYP2C9CYP1A2CYP3A4CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972961-A ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-10-26 US disclosed