Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.64 |
| ▸ | CA2 | P00918 | 2/20 | 0.64 |
| ▸ | CA4 | P22748 | 2/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.64 |
| ▸ | TACR1 | P25103 | 13/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478445 | 0.86 | CA1 (0.48) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL13980760 | 0.84 | TACR1 (0.63) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL7823087 | 0.83 | TACR1 (0.66) | CA1CA2CA4CA9TACR1 | |
| Hydrochloric Acid SCHEMBL8475576 | 0.82 | TACR1 (0.64) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL7830134 | 0.81 | DNMT1 (0.48) | CA1CA2CA4CA9TACR1 | |
| SCHEMBL28045116 | 0.81 | CA1 (0.62) | CA1CA2CA4CA9REN | |
| SCHEMBL590923 | 0.81 | CA1 (0.62) | CA1CA2CA4CA9REN | |
| SCHEMBL7475303 | 0.79 | CA1 (0.56) | CA1CA2CA4CA9HCRTR1 | |
| SCHEMBL4283232 | 0.79 | CA1 (0.61) | CA1CA2CA4CA9HCRTR1 | |
| SCHEMBL7864826 | 0.79 | TACR1 (0.71) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |