SCHEMBL8480461

SCHEMBL8480461

O=C(O)C1CN[C@@H](C(=O)O)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 1.00
CYP1A2 P05177 2/20 1.00
ALOX15 P16050 2/20 1.00
CYP2C19 P33261 2/20 1.00
SLC1A3 P43003 1/20 1.00
SLC1A2 P43004 1/20 1.00
SLC1A1 P43005 1/20 1.00
TSHR P16473 3/20 0.48
LMNA P02545 2/20 0.48
BLM P54132 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
PMP22 Q01453 2/20 0.48
RAB9A P51151 1/20 0.48
THRB P10828 1/20 0.48
ARG1 P05089 1/20 0.46
KDM4E B2RXH2 1/20 0.39
GABRP O00591 1/20 0.37
GABRD O14764 1/20 0.37
GABRA1 P14867 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2559376 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL1133665 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL12648650 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL8480462 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL2808482 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL2484170 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL542244 1.00 CYP2D6 (1.00) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL17743411 0.98 CYP2D6 (0.95) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL21402235 0.98 CYP2D6 (0.95) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3
SCHEMBL6652332 0.86 CYP2D6 (0.75) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942537-A ADMINISTERING A L-TRANS PYRROLIDINE DERIVATIVE TO INHIBIT THE TRANSPORT OF L-GLUTAMATE OR L-ASPARTATE OR AN EXCITATORY AMINO ACID NEUROTRANSMITTER AWAY FROM A SYNAPSE COMPRISING CONTACTING SYNAPSE WITH PYRROLIDINE DERIVATIVE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-08-24 US disclosed
EP-0497895-A1 METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1992-08-12 EP disclosed
WO-1991006536-A1 METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1991-05-16 WO disclosed