Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137304 | 1.00 | CHRM5 (0.33) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL7151124 | 1.00 | CHRM5 (0.33) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL13922293 | 0.79 | — | — | |
| SCHEMBL540037 | 0.78 | ALDH1A1 (0.33) | — | |
| SCHEMBL8129180 | 0.77 | OGA (0.31) | — | |
| SCHEMBL8129184 | 0.77 | OGA (0.31) | — | |
| SCHEMBL573808 | 0.77 | CHRM5 (0.32) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL7149794 | 0.77 | CHRM5 (0.32) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL11413995 | 0.75 | CHRM5 (0.31) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL28058214 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5583222-A | ANTIINFLAMMATORY AGENTS FOR TREATMENT OF SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |