SCHEMBL8480798

SCHEMBL8480798

COC(=O)c1ccc(C(=O)c2c(O)cc(OC)cc2F)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.53
CA2 P00918 5/20 0.53
CYP3A4 P08684 3/20 0.53
HPGD P15428 2/20 0.53
CA12 O43570 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
POLB P06746 2/20 0.49
GAA P10253 2/20 0.49
CYP2D6 P10635 2/20 0.47
CYP2C19 P33261 2/20 0.47
XDH P47989 2/20 0.46
APP P05067 1/20 0.46
KDM4E B2RXH2 2/20 0.45
LMNA P02545 2/20 0.45
NFKB1 P19838 1/20 0.45
GFER P55789 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38661406 0.89 CYP2D6 (0.54) CA1CA2CYP3A4HPGDGAA
SCHEMBL8132899 0.87 MKNK2 (0.52) CA1CA2CYP3A4HPGDPOLB
SCHEMBL8481123 0.85 CA1 (0.53) CA1CA2CYP3A4GAACYP2D6
SCHEMBL8128739 0.79 EGFR (0.46) CA1CA2CYP3A4POLBCYP2D6
SCHEMBL4283203 0.78 MEN1 (0.47) CA1CA2CYP3A4HPGDPOLB
SCHEMBL775483 0.77 CYP3A4 (0.53) CYP3A4HPGDPOLBGAACYP2D6
SCHEMBL8017091 0.77 CYP3A4 (0.55) CA1CA2CYP3A4HPGDCA12
SCHEMBL8479501 0.77 CA1 (0.59) CA1CA2CA12CA7CA9
SCHEMBL7195213 0.76 POLB (0.55) CYP3A4HPGDPOLBGAACYP2C19
SCHEMBL31167179 0.76 CYP3A4 (0.66) CYP3A4HPGDPOLBGAACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5914406-A ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA HOFFMAN-LA ROCHE INC. (US) 1999-06-22 US disclosed
US-5750706-A TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA HOFFMANN-LA ROCHE INC. (US) 1998-05-12 US disclosed
US-5583222-A ANTIINFLAMMATORY AGENTS FOR TREATMENT OF SKIN DISORDERS HOFFMANN-LA ROCHE INC. (US) 1996-12-10 US disclosed