Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 12/20 | 0.68 |
| ▸ | TACR1 | P25103 | 11/20 | 0.68 |
| ▸ | TACR3 | P29371 | 2/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479221 | 0.92 | TACR2 (0.67) | TACR2TACR1TACR3 | |
| SCHEMBL8481894 | 0.92 | TACR2 (0.65) | TACR2TACR1TACR3 | |
| SCHEMBL8482762 | 0.91 | TACR1 (0.63) | TACR2TACR1TACR3 | |
| SCHEMBL8481916 | 0.90 | TACR1 (0.62) | TACR2TACR1TACR3 | |
| SCHEMBL6950402 | 0.86 | TACR1 (0.61) | TACR2TACR1TACR3 | |
| SCHEMBL7873214 | 0.85 | TACR1 (0.59) | TACR2TACR1TACR3 | |
| SCHEMBL8482751 | 0.84 | TACR2 (0.67) | TACR2TACR1TACR3CCR5 | |
| Saredutant SCHEMBL185911 | 0.81 | TACR2 (1.00) | TACR2TACR1 | |
| Saredutant SCHEMBL676170 | 0.81 | TACR2 (1.00) | TACR2TACR1 | |
| Saredutant SCHEMBL29371280 | 0.81 | TACR2 (1.00) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008223-A | ANTIINFLAMMATORY AGENTS FOR TREATING ASTHMA | ZENECA LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5731309-A | Substituted heteroalkyleneamine neurokinin antagonists | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | disclosed |