Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 5/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | ACP1 | P24666 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185194 | 0.78 | PPARG (0.57) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL2181592 | 0.78 | PPARG (0.81) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL3421118 | 0.78 | PPARG (0.62) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL2334416 | 0.76 | PPARG (0.55) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL8484064 | 0.76 | PPARG (0.60) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL2182484 | 0.76 | PPARG (0.91) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL365536 | 0.75 | ESR1 (0.65) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL17159756 | 0.75 | PPARG (0.62) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL14185242 | 0.74 | PPARG (0.65) | PPARGESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL14185183 | 0.73 | PPARG (0.63) | PPARGESR1ESR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | VALLEE BERT L | 2007-11-22 | — | — | US | disclosed |
| EP-1077697-B1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ENDOWMENT FOR RES IN HUMAN BIO (US) | 2006-07-19 | — | — | EP | disclosed |
| EP-1645272-A2 | Daidzin derivatives for the treatment of alcohol dependence or alcohol abuse | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1077697-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6121010-A | SCREENING FOR COMPOUNDS WHICH REDUCE ALCOHOL (ETHANOL) CONSUMPTION BY DETERMINING EFFECTIVENESS FOR INHIBITING ALDEHYDE DEHYDROGENASE ACTIVITY ON ALDEHYDES DERIVED FROM SUBSTRATES OF MONOAMINE OXIDASE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999058124-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ADH1A, ADH5, ADH1C | PPARG 1086/4885ESR1 4519/4885ESR2 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.