Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979992 | 0.90 | LSS (0.48) | LSSPDPK1HSP90AB1TP53MAPT | |
| SCHEMBL8481582 | 0.80 | LSS (0.55) | LSSMAPT | |
| SCHEMBL5043141 | 0.77 | MIF (0.42) | LSSPDPK1HSP90AB1MAPTFGFR1 | |
| SCHEMBL5039013 | 0.77 | ESR1 (0.48) | PDPK1HSP90AB1ESR1ESR2 | |
| SCHEMBL21609563 | 0.75 | ALOX15 (0.35) | LSSPDPK1ESR2 | |
| SCHEMBL5037998 | 0.74 | MAPK1 (0.49) | PDPK1HSP90AB1ESR1ESR2 | |
| SCHEMBL8484965 | 0.74 | LSS (0.56) | LSSMAPT | |
| SCHEMBL3981917 | 0.74 | LSS (0.71) | LSS | |
| SCHEMBL8484967 | 0.73 | LSS (0.66) | LSSMAPT | |
| SCHEMBL5039610 | 0.73 | LSS (0.64) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856503-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |