Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | OGA | O60502 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502509 | 0.79 | RAB9A (0.53) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL14078321 | 0.78 | CYP3A4 (0.49) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL23377838 | 0.76 | MAPT (0.45) | MAPTRAB9ANPC1CYP1A2CYP2C9 | |
| SCHEMBL6138702 | 0.76 | RAB9A (0.56) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL23377841 | 0.76 | MAPT (0.45) | MAPTRAB9ANPC1CYP1A2CYP2C9 | |
| SCHEMBL3144643 | 0.76 | RAB9A (0.50) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL8249411 | 0.76 | RAB9A (0.50) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL15239118 | 0.76 | RAB9A (0.50) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| SCHEMBL8485071 | 0.75 | MAPT (0.42) | MAPTRAB9ACYP3A4NPC1CYP1A2 | |
| Hydrochloric Acid SCHEMBL4585660 | 0.75 | RAB9A (0.49) | MAPTRAB9ACYP3A4NPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |