Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 7/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 2/20 | 0.30 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL850524 | 0.95 | PTH1R (0.37) | PTH1RTACR1CETPADAMTS4MMP2 | |
| SCHEMBL16358633 | 0.92 | PTH1R (0.38) | PTH1RTACR1CETPADAMTS4MMP2 | |
| SCHEMBL16302620 | 0.92 | PTH1R (0.38) | PTH1RTACR1CETPADAMTS4MMP2 | |
| SCHEMBL16302629 | 0.91 | PTH1R (0.37) | PTH1RTACR1CETPADAMTS4MMP2 | |
| SCHEMBL849355 | 0.88 | PTH1R (0.35) | PTH1RADAMTS4MMP2MMP13MMP14 | |
| SCHEMBL851141 | 0.86 | PTH1R (0.47) | PTH1RTACR1CETPADAMTS4MMP2 | |
| SCHEMBL851594 | 0.86 | PTH1R (0.35) | PTH1RTACR1 | |
| SCHEMBL16358669 | 0.85 | PTH1R (0.36) | PTH1RTACR1 | |
| SCHEMBL16358785 | 0.83 | PTH1R (0.36) | PTH1RTACR1 | |
| SCHEMBL851265 | 0.83 | PTH1R (0.35) | PTH1RADAMTS4MMP2MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433940-B9 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |
| EP-2433940-A1 | SPIROIMIDAZOLONE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-03-28 | — | — | EP | disclosed |