Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485488 | 1.00 | KDM4E (0.50) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL6677378 | 0.95 | KDM4E (0.51) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL6677372 | 0.95 | KDM4E (0.51) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL4230548 | 0.86 | CCR8 (0.36) | KDM4ECA1CA2CCR8KCNH2 | |
| SCHEMBL6677459 | 0.79 | TRPM8 (0.35) | KDM4ECCR8KCNH2MAOBSMN1; SMN2 | |
| SCHEMBL6677454 | 0.79 | TRPM8 (0.35) | KDM4ECCR8KCNH2MAOBSMN1; SMN2 | |
| SCHEMBL8486991 | 0.76 | KDM4E (0.62) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL8486988 | 0.76 | KDM4E (0.62) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL8484974 | 0.74 | KDM4E (0.50) | KDM4ECA1CA2NFKB1CA4 | |
| SCHEMBL8484973 | 0.74 | KDM4E (0.50) | KDM4ECA1CA2NFKB1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856529-A | ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-05 | — | — | US | disclosed |