Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.31 |
| ▸ | UGCG | Q16739 | 2/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257458 | 1.00 | REN (0.42) | RENAXLMERTKGBA1UGCG | |
| SCHEMBL2340846 | 1.00 | REN (0.42) | RENAXLMERTKGBA1UGCG | |
| SCHEMBL2340323 | 0.90 | REN (0.45) | REN | |
| SCHEMBL14257433 | 0.90 | REN (0.45) | REN | |
| SCHEMBL2685143 | 0.90 | REN (0.51) | RENGBA1UGCGGBA2 | |
| SCHEMBL8487118 | 0.90 | REN (0.42) | RENAXLMERTKGBA1UGCG | |
| SCHEMBL4883249 | 0.90 | REN (0.42) | RENAXLMERTKGBA1UGCG | |
| SCHEMBL1036574 | 0.88 | REN (0.47) | RENGBA1UGCGGBA2 | |
| SCHEMBL14432970 | 0.88 | REN (0.43) | REN | |
| SCHEMBL2685315 | 0.88 | REN (0.47) | RENGBA1UGCGGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2163245-A1 | Renin inhibitors for the treatment of psoriasis | Novartis Ag (CH) | 2010-03-17 | — | — | EP | disclosed |