Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 12/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804 | 0.92 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2803 | 0.92 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8806218 | 0.91 | AGTR1 (0.61) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8482249 | 0.91 | AGTR1 (0.63) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8813643 | 0.89 | AGTR1 (0.58) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8487726 | 0.86 | AGTR1 (0.60) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8485808 | 0.86 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8482350 | 0.84 | AGTR1 (0.57) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL8486308 | 0.83 | AGTR1 (0.49) | AGTR1LTB4R2ABCB11GP6PTGDR2 | |
| SCHEMBL12600308 | 0.83 | AGTR1 (0.62) | AGTR1LTB4R2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |