Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995247 | 0.89 | EGFR (0.62) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8483701 | 0.87 | EGFR (0.55) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8488257 | 0.86 | EGFR (0.59) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8320166 | 0.84 | EGFR (0.67) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8484445 | 0.84 | EGFR (0.62) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998277 | 0.84 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8316917 | 0.84 | EGFR (0.71) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6994133 | 0.84 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998251 | 0.83 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6990982 | 0.83 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977102-A | INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES OR EPIDERMAL GROWTH FACTOR; ANTITUMOR,-CARCINOGENIC, -METASTASIS,-PROLIFERATION AGENTS AND -INFLAMMATORY AGENTS; PSORIASIS; ANGIOGENESIS INHIBITORS; IMMUNOLOGY; | DR. KARL THOMAE GMBH (DE) | 1999-11-02 | — | — | US | disclosed |