SCHEMBL8487167

SCHEMBL8487167

CSc1cc(Cl)cc(Cl)c1.Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.38
IDO1 P14902 1/20 0.31
TP53 P04637 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1713075 0.87 TSHR (0.50) TSHRTP53CYP3A4
SCHEMBL3784461 0.82 TSHR (0.41) TSHRTP53CYP3A4
SCHEMBL441794 0.79
SCHEMBL5181052 0.76
SCHEMBL26611232 0.76
SCHEMBL9910728 0.73 RAPGEF4 (0.34) TSHRIDO1
SCHEMBL8487655 0.73 TSHR (0.35) TSHR
SCHEMBL3790647 0.73
SCHEMBL16951388 0.71 TSHR (0.32) TSHR
SCHEMBL15279054 0.71 RAPGEF4 (0.36) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5932731-A HYDROLYZING A HETEROAROMATIC HALOGENATED METHYL SULFIDE IN PRESENCE OF AN ACID SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1999-08-03 US disclosed
US-5741933-A HYDROLYSIS; OXIDATION SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1998-04-21 US disclosed