Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 18/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apafant SCHEMBL94167 | 0.88 | PTAFR (1.00) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Apafant SCHEMBL29528926 | 0.88 | PTAFR (1.00) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9421182 | 0.88 | PTAFR (0.59) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9662020 | 0.84 | PTAFR (0.57) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| Apafant SCHEMBL1189235 | 0.84 | PTAFR (0.91) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9661933 | 0.83 | PTAFR (0.54) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10869807 | 0.82 | PTAFR (0.53) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL9661967 | 0.81 | PTAFR (0.87) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL8879466 | 0.80 | OPRK1 (0.74) | PTAFRCYP3A4ALOX15OPRK1PDE4D | |
| SCHEMBL10508885 | 0.79 | OPRK1 (0.53) | PTAFRCYP3A4ALOX15OPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5895785-A | ADMINISTERING ANTAGONIST THAT IS ONE OR MORE GINKGOLIDES | Korth, Ruth (DE) | 1999-04-20 | — | — | US | disclosed |
| EP-0604830-B1 | Use of at least one PAF-antagonist for the manufacture of a medicament in the treatment or prevention of hyperinsulinism | KORTH RUTH MARIA (DE) | 1998-09-30 | — | — | EP | disclosed |