Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3900914 | 0.79 | CHEK1 (0.43) | DYRK1ADYRK2DYRK1BPIM1IDO1 | |
| SCHEMBL17643659 | 0.76 | IDO1 (0.42) | NPC1RAB9ADYRK1APOLBIDO1 | |
| SCHEMBL15637899 | 0.75 | KCNA5 (0.45) | MAPTDYRK1ADYRK2DYRK1BPIM1 | |
| SCHEMBL15638356 | 0.73 | CD38 (0.46) | DYRK1ADYRK2DYRK1BPIM1KMT2A | |
| SCHEMBL26259995 | 0.72 | TBXAS1 (0.44) | NPC1DYRK1ADYRK2DYRK1BPIM1 | |
| SCHEMBL30761165 | 0.72 | CHEK1 (0.45) | MAPTDYRK1ADYRK2DYRK1BIDO1 | |
| SCHEMBL30761163 | 0.72 | CHEK1 (0.45) | MAPTDYRK1ADYRK2DYRK1BIDO1 | |
| SCHEMBL28019354 | 0.72 | DYRK1A (0.40) | NPC1RAB9AMAPTDYRK1ADYRK2 | |
| SCHEMBL28019355 | 0.72 | CYP2A6 (0.41) | NPC1RAB9APKMDYRK1ADYRK2 | |
| SCHEMBL16646852 | 0.72 | KDM4E (0.44) | NPC1RAB9ADYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536507-B | 2, 3-disubstituted pyridine compounds as TGF- β inhibitors and methods of use thereof | 里格尔药品股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| EP-2903978-A1 | GDF-8 INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2015025172-A1 | 5-ARYL-THIAZOL-2-YL-AMINE COMPOUNDS AND THEIR THERAPEUTIC USE | CHARLES MARK DAVID (GB) | 2015-02-26 | — | — | WO | disclosed |
| WO-2015025172-A1 | 5-ARYL-THIAZOL-2-YL-AMINE COMPOUNDS AND THEIR THERAPEUTIC USE | CHARLES MARK DAVID (GB) | 2015-02-26 | — | — | WO | disclosed |
| WO-2014055955-A1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2014-04-10 | — | — | WO | disclosed |
| US-5919779-A | VIRICIDE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-07-06 | — | — | US | disclosed |