Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189 | 0.92 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8484103 | 0.91 | AGTR1 (0.47) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL8483304 | 0.87 | LTB4R2 (0.42) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL2570 | 0.83 | AGTR1 (0.53) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8482137 | 0.83 | AGTR1 (0.43) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL7271922 | 0.82 | AGTR1 (0.49) | AGTR1LTB4R2ABCB11GP6AGTR2 | |
| SCHEMBL3087 | 0.82 | AGTR1 (0.55) | AGTR1LTB4R2ABCB11GP6AGTR2 | |
| SCHEMBL8483446 | 0.82 | AGTR1 (0.43) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL8487726 | 0.82 | AGTR1 (0.60) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL8482593 | 0.81 | AGTR1 (0.43) | AGTR1LTB4R2PTGDR2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | claimed |
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | claimed |