Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.67 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486786 | 0.90 | TOP2A (0.55) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8488702 | 0.89 | TOP2A (0.67) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8486796 | 0.88 | TOP2A (0.52) | TOP2ATOP2BPARP1MAPTKMT2A | |
| SCHEMBL8490361 | 0.86 | TOP2A (0.80) | TOP2ATOP2BKDM1AMAPTL3MBTL1 | |
| SCHEMBL8489520 | 0.80 | TOP2A (1.00) | TOP2ATOP2BKDM1AMAPTL3MBTL1 | |
| SCHEMBL8489781 | 0.79 | TOP2A (0.67) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8487444 | 0.78 | TOP2A (0.54) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8489125 | 0.77 | TOP2A (0.66) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL9299946 | 0.76 | TOP2A (0.72) | TOP2ATOP2BKDM1AMAPTL3MBTL1 | |
| SCHEMBL3981533 | 0.74 | TOP2A (0.80) | TOP2ATOP2BKDM1AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939428-A | ANTITUMOR AGENTS AND ANTIGROWTH AGENTS FOR CELLS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 1999-08-17 | — | — | US | disclosed |