Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.67 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487444 | 0.89 | TOP2A (0.54) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8488258 | 0.89 | TOP2A (0.67) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8489781 | 0.88 | TOP2A (0.67) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8489125 | 0.87 | TOP2A (0.66) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8489010 | 0.84 | TOP2A (0.78) | TOP2ATOP2BPARP1CYP3A4CYP2C9 | |
| SCHEMBL8489028 | 0.84 | TOP2A (0.73) | TOP2ATOP2BKDM1A | |
| SCHEMBL8484693 | 0.82 | TOP2A (0.73) | TOP2ATOP2BKDM1A | |
| SCHEMBL29536689 | 0.82 | TOP2A (1.00) | TOP2ATOP2BHDAC4HDAC7HDAC6 | |
| SCHEMBL1865418 | 0.82 | TOP2A (1.00) | TOP2ATOP2BHDAC4HDAC7HDAC6 | |
| SCHEMBL3985902 | 0.81 | TOP2A (0.71) | TOP2ATOP2BPARP1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939428-A | ANTITUMOR AGENTS AND ANTIGROWTH AGENTS FOR CELLS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 1999-08-17 | — | — | US | disclosed |