Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.65 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.60 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508539 | 0.83 | PDE10A (0.55) | HSP90AA1HSP90AB1PDE10AGPR35MAPT | |
| SCHEMBL27535082 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AGPR35MAPT | |
| SCHEMBL29801038 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AMAPTALDH1A1 | |
| SCHEMBL2195087 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AGPR35MAPT | |
| SCHEMBL3713823 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AGPR35MAPT | |
| SCHEMBL6431603 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AGPR35MAPT | |
| SCHEMBL7795676 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AMAPTALDH1A1 | |
| SCHEMBL29253980 | 0.80 | PDE10A (0.60) | HSP90AA1HSP90AB1PDE10AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL9674734 | 0.79 | PDE10A (0.58) | HSP90AA1HSP90AB1PDE10AMAPTALDH1A1 | |
| SCHEMBL2227640 | 0.79 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1PDE10AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242943-B2 | 1,4 oxazines as BACE1 and/or BACE2 inhibitors | SIENA BIOTECH S.P.A. (IT) | 2016-01-26 | — | — | US | disclosed |
| EP-2665713-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| CN-103328454-A | 1,4 oxazines as BACE1 and/or BACE2 inhibitors | HOFFMANN LA ROCHE | 2013-09-25 | — | — | CN | disclosed |
| WO-2012098064-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184540-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-19 | — | — | US | disclosed |
| WO-1999001442-A1 | TRIAZINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ZENECA LIMITED (GB) | 1999-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184540-A1 | 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | BACE2, BACE1, PSEN1 | HSP90AA1 3353/4885HSP90AB1 1953/4885PDE10A 3411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.