Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483155 | 1.00 | NPC1 (0.55) | NPC1RAB9AGAAKEAP1NFE2L2 | |
| SCHEMBL9235231 | 0.96 | NPC1 (0.57) | NPC1RAB9AGAAKEAP1NFE2L2 | |
| SCHEMBL9541840 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAMGLL | |
| SCHEMBL8487757 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAKEAP1NFE2L2 | |
| SCHEMBL9682837 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAMGLL | |
| SCHEMBL9542179 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAMGLL | |
| SCHEMBL9681832 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAMGLL | |
| SCHEMBL9543483 | 0.91 | NPC1 (0.54) | NPC1RAB9AGAAMGLL | |
| SCHEMBL9540810 | 0.89 | NPC1 (0.54) | NPC1RAB9AGAAMGLLUSP2 | |
| SCHEMBL9541815 | 0.89 | NPC1 (0.56) | NPC1RAB9AGAAKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952354-A | ENZYME INHIBITORS OF CHLOESTEROL ESTER HYDROLASE AND/OR ACYL COENZYME A:CHLOESTEROL ACYLTRANSFERASE; INHIBIT THE ESTERIFICATION OF CHLOESTEROL AND REDUCE ABSORPTION THROUGH THE INTESTINE; CARBAMATES OF 4-8 MEMBERED AZACYCLOALKANOLS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0635501-A1 | Tris carbamic acid esters: inhibitors of cholesterol absorption; inhibitors of ACAT and CEH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-25 | — | — | EP | disclosed |