Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487531 | 0.88 | HTR6 (0.38) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL8488870 | 0.88 | BRD4 (0.41) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL3347141 | 0.85 | HTR6 (0.38) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL3354296 | 0.85 | HTR6 (0.43) | HTR6BRD4PTPN11DRD2HTR2A | |
| SCHEMBL13745685 | 0.85 | PTPN11 (0.42) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL8192188 | 0.83 | PDPK1 (0.47) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL13746471 | 0.82 | PTPN11 (0.43) | HTR6BRD4PTPN11DRD2HTR2A | |
| SCHEMBL1487587 | 0.82 | PIK3CA (0.39) | BRD4 | |
| SCHEMBL13746277 | 0.82 | PTPN11 (0.41) | HTR6BRD4PTPN11CA12CA9 | |
| SCHEMBL13745691 | 0.82 | BRD4 (0.41) | HTR6BRD4PTPN11CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |