Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150558 | 0.85 | EGFR (0.76) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7243231 | 0.78 | AURKA (0.52) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7242229 | 0.78 | EGFR (0.65) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7235041 | 0.77 | EGFR (0.79) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7235049 | 0.77 | EGFR (0.79) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL8149145 | 0.76 | EGFR (0.66) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7243002 | 0.76 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239777 | 0.76 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7239782 | 0.76 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7243000 | 0.76 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |