Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13864821 | 1.00 | ALDH1A1 (0.50) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL701943 | 0.89 | GAA (0.56) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL2978403 | 0.89 | GAA (0.56) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL12311388 | 0.88 | PDE4B (0.43) | ALDH1A1THRBATML3MBTL1GAA | |
| Hydrochloric Acid SCHEMBL8307643 | 0.87 | GAA (0.54) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL18849447 | 0.86 | GAA (0.57) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL4863171 | 0.86 | GAA (0.57) | ALDH1A1THRBATML3MBTL1GAA | |
| SCHEMBL3649936 | 0.85 | POLB (0.51) | ALDH1A1PRMT5WDR77POLBCA12 | |
| SCHEMBL30497646 | 0.85 | POLB (0.51) | ALDH1A1PRMT5WDR77POLBCA12 | |
| SCHEMBL3649934 | 0.85 | POLB (0.51) | ALDH1A1PRMT5WDR77POLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846931-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| EP-1699797-B1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2009-02-19 | — | — | US | disclosed |
| US-7297695-B2 | Pyrrolotriazine compounds as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-20 | — | — | US | disclosed |
| WO-1999032481-A1 | MUSCARINIC AGENTS AND USE THEREOF TO TREAT GLAUCOMA, MYOPIA AND VARIOUS OTHER CONDITIONS | ALCON LABORATORIES, INC. (US) | 1999-07-01 | — | — | WO | disclosed |
| EP-0111864-B1 | 1,4-BENZODIAZEPINE DERIVATIVES | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1990-03-07 | — | — | EP | disclosed |
| US-4560684-A | ANTIDEPRESSANTS; NERVOUS SYSTEM DISORDERS | SHIONOGI & CO., LTD. (JP) | 1985-12-24 | — | — | US | disclosed |
| EP-0111864-A1 | 1,4-Benzodiazepine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1984-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048244-A1 | PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS | ERBB2, ERBB4, ERBB3 | ALDH1A1 3252/4885THRB 380/4885ATM 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.