Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.42 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524296 | 0.84 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL7232352 | 0.84 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL8488803 | 0.83 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| Morpholine SCHEMBL7243744 | 0.81 | MAPK14 (0.35) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL7420770 | 0.70 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL4553843 | 0.70 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5082085 | 0.68 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| Morpholine SCHEMBL4553844 | 0.67 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12GCGR | |
| SCHEMBL4566366 | 0.67 | ADORA2A (0.46) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| Morpholine SCHEMBL7387653 | 0.66 | MAPK14 (0.39) | MAPK14MAPK11MAPK13MAPK12GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916891-A | CYTOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-29 | — | — | US | disclosed |