SCHEMBL8491985

SCHEMBL8491985

Brc1cccc(COc2ncccn2)c1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 13/20 0.62
IDO1 P14902 2/20 0.56
AGXT P21549 2/20 0.56
MAOA P21397 4/20 0.50
PARP15 Q460N3 2/20 0.49
PARP10 Q53GL7 2/20 0.49
PARP14 Q460N5 1/20 0.49
FFAR1 O14842 1/20 0.47
FFAR4 Q5NUL3 1/20 0.47
ESR1 P03372 1/20 0.46
NR3C1 P04150 1/20 0.46
PGR P06401 1/20 0.46
NR3C2 P08235 1/20 0.46
AR P10275 1/20 0.46
THRA P10827 1/20 0.46
THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31173205 0.81 NPC1 (0.58) MAOBIDO1AGXTMAOAPARP15
SCHEMBL22290322 0.81 NPC1 (0.58) MAOBIDO1AGXTMAOAPARP15
SCHEMBL31173412 0.79 MAOB (0.69) MAOBIDO1AGXTMAOAPARP15
SCHEMBL22290667 0.79 MAOB (0.69) MAOBIDO1AGXTMAOAPARP15
SCHEMBL8488996 0.78 MAOB (0.60) MAOBIDO1MAOATHRATHRB
SCHEMBL4404036 0.77 MAOB (1.00) MAOBIDO1AGXTMAOAPARP15
SCHEMBL12256032 0.76 MAOB (0.66) MAOBIDO1AGXTMAOAPARP15
SCHEMBL27844033 0.76 NPC1 (0.62) MAOB
SCHEMBL2779108 0.76 LTA4H (0.55) MAOBIDO1AGXTMAOA
SCHEMBL1767187 0.76 IDO1 (0.69) MAOBIDO1AGXTMAOAPARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999019304-A9 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS UPJOHN CO (US) 1999-07-08 WO disclosed