Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492223 | 1.00 | SERPINE1 (0.59) | SERPINE1EGFRERBB2ALDH1A1GSK3B | |
| SCHEMBL8495028 | 0.90 | SERPINE1 (0.59) | SERPINE1CYP1A2CYP2C19KMT2AHPGD | |
| SCHEMBL8495025 | 0.90 | SERPINE1 (0.59) | SERPINE1CYP1A2CYP2C19KMT2AHPGD | |
| SCHEMBL6374340 | 0.83 | SERPINE1 (0.63) | SERPINE1GSK3BMETAP1MAPTKMT2A | |
| SCHEMBL6374330 | 0.83 | SERPINE1 (0.63) | SERPINE1GSK3BMETAP1MAPTKMT2A | |
| SCHEMBL6373443 | 0.81 | SERPINE1 (0.68) | SERPINE1ALDH1A1GSK3BMETAP1MEN1 | |
| SCHEMBL6373441 | 0.81 | SERPINE1 (0.68) | SERPINE1ALDH1A1GSK3BMETAP1MEN1 | |
| SCHEMBL8490770 | 0.80 | RET (0.57) | SERPINE1EGFRERBB2MEN1MAPT | |
| SCHEMBL8490766 | 0.80 | RET (0.57) | SERPINE1EGFRERBB2MEN1MAPT | |
| SCHEMBL6374498 | 0.77 | SERPINE1 (0.70) | SERPINE1ALDH1A1GSK3BCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | claimed |
| EP-0745069-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | claimed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |