Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | SERPINE1 | P05121 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490766 | 1.00 | RET (0.57) | RETSERPINE1KMT2ASMN1; SMN2EGFR | |
| SCHEMBL8838101 | 0.86 | SERPINE1 (0.61) | RETSERPINE1KMT2ASMN1; SMN2EGFR | |
| SCHEMBL8727134 | 0.82 | KMT2A (0.61) | RETKMT2ASMN1; SMN2EGFRERBB2 | |
| SCHEMBL8495431 | 0.82 | SERPINE1 (0.62) | SERPINE1 | |
| SCHEMBL8495426 | 0.82 | SERPINE1 (0.62) | SERPINE1 | |
| SCHEMBL6380223 | 0.80 | SERPINE1 (0.67) | SERPINE1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL6380230 | 0.80 | SERPINE1 (0.67) | SERPINE1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL8492223 | 0.80 | SERPINE1 (0.59) | SERPINE1KMT2AEGFRERBB2HPGD | |
| SCHEMBL8492220 | 0.80 | SERPINE1 (0.59) | SERPINE1KMT2AEGFRERBB2HPGD | |
| SCHEMBL6373443 | 0.79 | SERPINE1 (0.68) | SERPINE1KMT2ASMN1; SMN2MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902812-A | Pharmaceutical piperazine compounds | XENOVA LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| EP-0745069-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021829-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |