Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 10/20 | 0.97 |
| ▸ | CA2 | P00918 | 10/20 | 0.97 |
| ▸ | CA4 | P22748 | 10/20 | 0.97 |
| ▸ | CA7 | P43166 | 10/20 | 0.97 |
| ▸ | CA9 | Q16790 | 10/20 | 0.97 |
| ▸ | CA1 | P00915 | 8/20 | 0.97 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | PRKX | P51817 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492205 | 0.98 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL7954369 | 0.87 | CA12 (0.80) | CA12CA2CA4CA7CA9 | |
| SCHEMBL8491719 | 0.79 | CA12 (0.68) | CA12CA2CA4CA7CA9 | |
| SCHEMBL29766350 | 0.77 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL16277684 | 0.77 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL375359 | 0.77 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL4500272 | 0.77 | CA12 (1.00) | CA12CA2CA4CA7CA9 | |
| SCHEMBL9283155 | 0.75 | CA2 (0.62) | CA12CA2CA4CA7CA9 | |
| SCHEMBL30885714 | 0.75 | CA12 (0.61) | CA12CA2CA4CA7CA9 | |
| SCHEMBL29766441 | 0.74 | CA12 (1.00) | CA12CA2CA4CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999032467-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-07-01 | — | — | WO | disclosed |