Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81134 | 0.81 | KDM4E (0.60) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL28477473 | 0.81 | MEN1 (0.60) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL31236129 | 0.81 | KDM4E (0.60) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL15778299 | 0.81 | AKT1 (0.72) | KDM4EMAPTGAAPOLBL3MBTL1 | |
| SCHEMBL2348513 | 0.80 | KDM5A (0.57) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL28478726 | 0.80 | MEN1 (0.58) | KDM5AKDM4EMAPTGAACA1 | |
| Hydrochloric Acid SCHEMBL8887014 | 0.79 | KDM5A (0.56) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL13064965 | 0.77 | TOP1 (0.62) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL2213755 | 0.77 | KDM5A (0.62) | KDM5AKDM4EMAPTGAACA1 | |
| SCHEMBL9621823 | 0.76 | KDM5A (0.53) | KDM5AKDM4EMAPTGAACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886044-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-03-23 | — | — | US | disclosed |
| US-5780483-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |