Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.62 |
| ▸ | TOP2A | P11388 | 3/20 | 0.62 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.62 |
| ▸ | KDM5A | P29375 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA6 | P23280 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 4/20 | 0.53 |
| ▸ | SELL | P14151 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064964 | 0.88 | TOP1 (0.64) | TOP1TOP2ATOP2BKDM5AKDM4E | |
| SCHEMBL28477473 | 0.88 | MEN1 (0.60) | TOP1KDM5AKDM4ECA12CA1 | |
| SCHEMBL28478726 | 0.86 | MEN1 (0.58) | TOP1KDM5AKDM4ECA12CA1 | |
| SCHEMBL12704788 | 0.82 | NPC1 (0.77) | KDM5AMAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL29692929 | 0.81 | KDM5A (0.59) | TOP1TOP2ATOP2BKDM5AKDM4E | |
| SCHEMBL18027729 | 0.80 | KCNMA1 (0.71) | TOP1TOP2ATOP2BMAPTGAA | |
| SCHEMBL18993374 | 0.80 | TOP1 (0.62) | TOP1TOP2ATOP2BKDM4EMAPT | |
| SCHEMBL13064992 | 0.79 | TOP1 (0.82) | TOP1TOP2ATOP2BKDM4ECA12 | |
| SCHEMBL12704786 | 0.78 | GAA (0.52) | TOP1KDM5AKDM4ECA12CA1 | |
| SCHEMBL12707445 | 0.78 | KDM5A (0.53) | KDM5APOLBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9052324-B2 | Compounds and assays for controlling Wnt activity | ENZO BIOCHEM, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20120322717-A9 | Compounds and assays for controlling Wnt activity | ENZO BIOCHEM, INC. | 2012-12-20 | — | — | US | disclosed |
| US-20100298200-A1 | Compounds and assays for controlling Wnt activity | LIU DAKAI | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322717-A9 | Compounds and assays for controlling Wnt activity | WNT1, WNT3A, WNT3 | TOP1 4169/4885TOP2A 4437/4885TOP2B 4174/4885 |
| US-20100298200-A1 | Compounds and assays for controlling Wnt activity | WNT1, WNT3A, WNT3 | TOP1 4169/4885TOP2A 4437/4885TOP2B 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.