Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 12/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499510 | 0.87 | CAPN1 (0.52) | CAPN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8497491 | 0.85 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL7344609 | 0.83 | CAPN1 (0.58) | CAPN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8499887 | 0.80 | CAPN1 (0.57) | CAPN1CHEK1JAK2 | |
| SCHEMBL8494762 | 0.79 | CAPN1 (0.58) | CAPN1 | |
| SCHEMBL8494767 | 0.77 | CAPN1 (0.58) | CAPN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8497568 | 0.76 | CAPN1 (0.57) | CAPN1CHEK1JAK2 | |
| SCHEMBL8500284 | 0.67 | CAPN1 (0.54) | CAPN1 | |
| SCHEMBL8498676 | 0.65 | CAPN1 (0.63) | CAPN1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8498077 | 0.62 | CAPN1 (0.61) | CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |