Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 9/20 | 0.63 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8495095 | 0.85 | CAPN1 (0.55) | CAPN1P2RX7POLBGRIA1GRIA2 | |
| SCHEMBL7344609 | 0.82 | CAPN1 (0.58) | CAPN1P2RX7POLBGRIA1GRIA2 | |
| SCHEMBL27825469 | 0.67 | AADAT (0.43) | P2RX7POLBGRIA1GRIA2GRIA3 | |
| SCHEMBL7351908 | 0.67 | CAPN1 (0.68) | CAPN1ACE | |
| SCHEMBL8494767 | 0.66 | CAPN1 (0.58) | CAPN1P2RX7GRIA1GRIA2GRIA3 | |
| SCHEMBL10920023 | 0.66 | ACE (0.70) | ACE | |
| SCHEMBL5563136 | 0.66 | ACE (0.48) | ACE | |
| SCHEMBL5563133 | 0.66 | ACE (0.48) | ACE | |
| SCHEMBL7316478 | 0.65 | ACE (0.53) | ACE | |
| SCHEMBL8495189 | 0.65 | CAPN1 (0.55) | CAPN1P2RX7POLBGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |