Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 7/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944612 | 0.86 | HSP90AA1 (0.51) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL8495356 | 0.78 | CSF1R (0.36) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| Dimethyladenine SCHEMBL29349831 | 0.73 | LRRK2 (1.00) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| Dimethyladenine SCHEMBL152594 | 0.73 | LRRK2 (1.00) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL28252229 | 0.72 | EGFR (0.76) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL28004890 | 0.72 | EGFR (0.66) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| Dimethyladenine SCHEMBL11157548 | 0.72 | PDPK1 (0.96) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL28004896 | 0.71 | EGFR (0.74) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL6517686 | 0.71 | LRRK2 (0.73) | EGFRCSF1RHSP90AA1PDPK1LRRK2 | |
| SCHEMBL30602928 | 0.71 | LRRK2 (0.73) | EGFRCSF1RHSP90AA1PDPK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821690-B1 | Nucleotide analogues for the treatment of viral infections | USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY (CZ) | 2012-06-13 | — | — | EP | disclosed |
| US-5977061-A | VIRICIDE AGAINST DNA VIRUSES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1999-11-02 | — | — | US | disclosed |
| EP-0821690-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky (CZ) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033200-A1 | NOVEL COMPOUNDS AND METHODS FOR THERAPY | ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AKADEMIE VED C^¿ESKÉ REPUBLIKY (CZ) | 1996-10-24 | — | — | WO | disclosed |