Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.73 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.73 |
| ▸ | PRKACA | P17612 | 1/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.73 |
| ▸ | CDK2 | P24941 | 1/20 | 0.73 |
| ▸ | MARK3 | P27448 | 1/20 | 0.73 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.73 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.73 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 8/20 | 0.58 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30602928 | 1.00 | LRRK2 (0.73) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL152594 | 0.85 | LRRK2 (1.00) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL29349831 | 0.85 | LRRK2 (1.00) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL30544086 | 0.85 | LRRK2 (0.67) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL11157548 | 0.83 | PDPK1 (0.96) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL9096944 | 0.79 | HSD17B10 (0.69) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL29368416 | 0.77 | PDPK1 (0.67) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL9203283 | 0.76 | HTT (0.76) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL29529931 | 0.76 | PDPK1 (0.66) | LRRK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL401116 | 0.76 | PDPK1 (0.66) | LRRK2PDPK1CHEK1AURKACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043268-A1 | Inhibition of viruses | MEDICAL RESEARCH COUNCIL (GB) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043268-A1 | Inhibition of viruses | RNASE1, HNRNPA1, RNASEH1 | LRRK2 4089/4885PDPK1 4629/4885CHEK1 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.