Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.74 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.74 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.74 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.74 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.74 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.74 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369562 | 0.85 | GRIN1 (1.00) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Water SCHEMBL30546080 | 0.84 | GRIN1 (0.97) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9452352 | 0.84 | GRIN1 (0.74) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9452300 | 0.83 | CYP1A2 (0.68) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL19131321 | 0.83 | GRIN1 (0.68) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL9452306 | 0.81 | GRIN1 (0.70) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Potassium SCHEMBL9452247 | 0.80 | GRIN1 (0.68) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL1618153 | 0.80 | HPGD (0.63) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL29617387 | 0.80 | HPGD (0.63) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Potassium Ion SCHEMBL9452243 | 0.79 | GRIN1 (0.67) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731791-B1 | BENZENESULFONYLIMINE DERIVATIVES AS INHIBITORS OF IL-1 ACTION | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5684017-A | ANTIARTHRITIC AGENTS, RHEUMATIC DISEASES, ANTIDIABETIC AGENTS FOR INHIBITING INTERLOEUKINS | MERRELL PHARMACEUTICALS INC. (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0731791-A1 | NOVEL BENZENESULFONYLIMINE DERIVATIVES AS INHIBITORS OF IL-1 ACTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995014669-A1 | NOVEL BENZENESULFONYLIMINE DERIVATIVES AS INHIBITORS OF IL-1 ACTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-01 | — | — | WO | disclosed |