SCHEMBL1618153

SCHEMBL1618153

CCOC(=O)c1cc(=O)c2c(Cl)cc(Cl)cc2[nH]1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.63
ALOX15 P16050 2/20 0.63
MEN1 O00255 2/20 0.63
KMT2A Q03164 2/20 0.63
GRIN2D O15399 1/20 0.63
GRIN3B O60391 1/20 0.63
CYP1A2 P05177 1/20 0.63
CYP2D6 P10635 1/20 0.63
CYP2C9 P11712 1/20 0.63
TSHR P16473 1/20 0.63
CYP2C19 P33261 1/20 0.63
BLM P54132 1/20 0.63
GRIN1 Q05586 1/20 0.63
GRIN2A Q12879 1/20 0.63
GRIN2B Q13224 1/20 0.63
GRIN2C Q14957 1/20 0.63
GRIN3A Q8TCU5 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
KDM4E B2RXH2 3/20 0.49
ALDH1A1 P00352 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29617387 1.00 HPGD (0.63) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452343 0.88 ALOX15 (0.50) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452270 0.88 ALOX15 (0.56) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452263 0.87 ALOX15 (0.55) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452307 0.87 ALOX15 (0.49) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452300 0.85 CYP1A2 (0.68) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452253 0.84 TSHR (0.54) HPGDALOX15MEN1KMT2AGRIN2D
Bromide SCHEMBL9452238 0.83 TSHR (0.53) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9452191 0.82 ALOX15 (0.54) HPGDALOX15MEN1KMT2AGRIN2D
SCHEMBL9501035 0.82 ALOX15 (0.54) HPGDALOX15MEN1KMT2AGRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4227297-A1 PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF Lohocla Research Corporation (US) 2023-08-16 EP disclosed
EP-4227297-A1 PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF Lohocla Research Corporation (US) 2023-08-16 EP disclosed
EP-4013416-A1 PROCESS FOR PREPARING 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLATES AND 4-AMINOQUINOLINE COMPOUNDS THEREFROM Lohocla Research Corporation (US) 2022-06-22 EP disclosed
US-20220162168-A1 PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF LOHOCLA RESEARCH CORPORATION 2022-05-26 US disclosed
US-20220162168-A1 PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF LOHOCLA RESEARCH CORPORATION 2022-05-26 US disclosed
WO-2021030511-A1 PROCESS FOR PREPARING 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLATES AND 4-AMINOQUINOLINE COMPOUNDS THEREFROM LOHOCLA RESEARCH CORPORATION (US) 2021-02-18 WO disclosed
WO-2021030511-A1 PROCESS FOR PREPARING 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLATES AND 4-AMINOQUINOLINE COMPOUNDS THEREFROM LOHOCLA RESEARCH CORPORATION (US) 2021-02-18 WO disclosed
US-10875831-B1 Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom LOHOCLA RESEARCH CORPORATION (US) 2020-12-29 US disclosed
US-10875831-B1 Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom LOHOCLA RESEARCH CORPORATION (US) 2020-12-29 US disclosed
US-20110184018-A1 METHOD FOR TREATING PERIPHERAL NEUROPATHIC PAIN LOHOCLA RESEARCH CORPORATION (US) 2011-07-28 US disclosed
US-20110184018-A1 METHOD FOR TREATING PERIPHERAL NEUROPATHIC PAIN LOHOCLA RESEARCH CORPORATION (US) 2011-07-28 US disclosed
US-7923458-B2 Method for treating chronic pain LOHOCLA RESEARCH CORPORATION (US) 2011-04-12 US disclosed
US-7923458-B2 Method for treating chronic pain LOHOCLA RESEARCH CORPORATION (US) 2011-04-12 US disclosed
US-7923458-B2 Method for treating chronic pain LOHOCLA RESEARCH CORPORATION (US) 2011-04-12 US disclosed
US-20090137627-A1 Method for Treating Chronic Pain LOHOCLA RESEARCH CORPORATION 2009-05-28 US disclosed
US-20090137627-A1 Method for Treating Chronic Pain LOHOCLA RESEARCH CORPORATION 2009-05-28 US disclosed
US-20090137627-A1 Method for Treating Chronic Pain LOHOCLA RESEARCH CORPORATION 2009-05-28 US disclosed
EP-1951238-A2 METHOD FOR TREATING CHRONIC PAIN Lohocla Research Corporation (US) 2008-08-06 EP disclosed
WO-2007044682-A2 METHOD FOR TREATING CHRONIC PAIN LOHOCLA RESEARCH CORPORATION (US) 2007-04-19 WO disclosed
WO-2007044682-A2 METHOD FOR TREATING CHRONIC PAIN LOHOCLA RESEARCH CORPORATION (US) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137627-A1 Method for Treating Chronic Pain OPRK1, AADAT, BDKRB2 HPGD 25/4885ALOX15 56/4885MEN1 4244/4885
US-20110184018-A1 METHOD FOR TREATING PERIPHERAL NEUROPATHIC PAIN CNR1, CNR2, OPRK1 HPGD 285/4885ALOX15 150/4885MEN1 3740/4885
US-10875831-B1 Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom KMO, THEM6, HADHA HPGD 337/4885ALOX15 136/4885MEN1 1735/4885
US-20220162168-A1 PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF KMO, KYNU, PAH HPGD 281/4885ALOX15 58/4885MEN1 637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.