SCHEMBL8496830

SCHEMBL8496830

Clc1ccc(C=NN(Cc2ccccc2)Cc2ccccc2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
G6PC1 P35575 16/20 1.00
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
NPC1 O15118 1/20 0.43
NFKB1 P19838 1/20 0.43
RAB9A P51151 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
LMNA P02545 1/20 0.43
ALDH1A1 P00352 2/20 0.42
HSP90AA1 P07900 1/20 0.42
GAA P10253 1/20 0.42
MCL1 Q07820 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8496828 1.00 G6PC1 (1.00) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8497015 0.93 G6PC1 (0.86) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8497020 0.93 G6PC1 (0.86) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL14799715 0.83 G6PC1 (0.92) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL14799714 0.83 G6PC1 (0.92) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8498198 0.82 G6PC1 (1.00) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8498194 0.82 G6PC1 (1.00) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL14799388 0.82 G6PC1 (0.82) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL14799390 0.82 G6PC1 (0.82) G6PC1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL8498260 0.81 G6PC1 (0.73) G6PC1MEN1KMT2AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999040062-A1 HYDRAZONE DERIVATIVES NOVO NORDISK A/S (DK) 1999-08-12 WO claimed