Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.51 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497079 | 1.00 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8826200 | 1.00 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8826205 | 1.00 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8498888 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL8825979 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL9263341 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL8825976 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL8494329 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL8494325 | 0.97 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL9114353 | 0.94 | LPAR1 (0.47) | LPAR1LPAR5HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |