Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498733 | 1.00 | LPAR1 (0.47) | LPAR1LPAR5HDAC1HDAC6ADAM17 | |
| SCHEMBL8498734 | 1.00 | LPAR1 (0.47) | LPAR1LPAR5HDAC1HDAC6ADAM17 | |
| SCHEMBL8826205 | 0.94 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8826200 | 0.94 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8497073 | 0.94 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8497079 | 0.94 | LPAR1 (0.51) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL8497870 | 0.93 | LPAR1 (0.47) | LPAR1LPAR5HDAC1HDAC6ADAM17 | |
| SCHEMBL8497876 | 0.93 | LPAR1 (0.47) | LPAR1LPAR5HDAC1HDAC6ADAM17 | |
| SCHEMBL8825979 | 0.91 | LPAR1 (0.48) | LPAR1LPAR5 | |
| SCHEMBL8825976 | 0.91 | LPAR1 (0.48) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |