SCHEMBL8497696

SCHEMBL8497696

COCC(CS)C(=O)OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
CPB2 Q96IY4 1/20 0.34
FOLH1 Q04609 2/20 0.32
CA14 Q9ULX7 1/20 0.31
MME P08473 1/20 0.31
ZDHHC7 Q9NXF8 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30
THRB P10828 1/20 0.30
ALOX15 P16050 1/20 0.30
NFKB1 P19838 1/20 0.30
PTGS2 P35354 1/20 0.30
THPO P40225 1/20 0.30
RECQL P46063 1/20 0.30
BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1504014 0.85 CA1 (0.46) CA1CA2TSHRKMT2ASMN1; SMN2
SCHEMBL2879991 0.85
SCHEMBL6741985 0.79
SCHEMBL2871738 0.77 CA1 (0.45) CA1CA2TSHRHSD17B10KMT2A
SCHEMBL14193621 0.76 BMP1 (0.44) CA1CA2TSHRHSD17B10KMT2A
SCHEMBL819943 0.76 MME (0.47) CA1CA2KMT2ASMN1; SMN2CA14
SCHEMBL4939390 0.76 CA1 (0.39) CA1CA2TSHRHSD17B10KMT2A
SCHEMBL28244713 0.76 CA1 (0.53) CA1CA2TSHRKMT2ASMN1; SMN2
SCHEMBL9818849 0.76 TSHR (0.46) CA1CA2TSHRHSD17B10KMT2A
SCHEMBL2880189 0.74 CA1 (0.52) CA1CA2TSHRHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5856322-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS MERCK FROSST CANADA, INC. (CA) 1999-01-05 US disclosed
EP-0480717-B1 Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists MERCK FROSST CANADA INC (CA) 1998-04-15 EP disclosed
US-5565473-A USEFUL AS ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND CYTOPROTECTIVE AGENTS; MONTELUKAST AND ITS SODIUM SALT MERCK FROSST CANADA, INC. (CA) 1996-10-15 US disclosed
US-5270324-A Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists MERCK FROSST CANADA, INC. (CA) 1993-12-14 US disclosed
EP-0480717-A1 Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists MERCK FROSST CANADA INC. (CA) 1992-04-15 EP disclosed