Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497894 | 1.00 | ALOX5 (0.44) | ALOX5LPAR1LPAR5BCHENR3C1 | |
| SCHEMBL9094732 | 0.97 | FABP7 (0.43) | ALOX5LPAR1LPAR5 | |
| SCHEMBL8496862 | 0.87 | LPAR1 (0.48) | LPAR1LPAR5NR3C1 | |
| SCHEMBL8496866 | 0.87 | LPAR1 (0.48) | LPAR1LPAR5NR3C1 | |
| SCHEMBL8694372 | 0.86 | LPAR1 (0.40) | ALOX5LPAR1LPAR5 | |
| SCHEMBL9096734 | 0.86 | LPAR1 (0.46) | LPAR1LPAR5 | |
| SCHEMBL9094317 | 0.85 | FABP7 (0.46) | LPAR1LPAR5 | |
| SCHEMBL9094513 | 0.85 | FABP7 (0.46) | LPAR1LPAR5 | |
| SCHEMBL8497805 | 0.84 | LPAR1 (0.44) | LPAR1LPAR5 | |
| SCHEMBL8497804 | 0.84 | LPAR1 (0.44) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |