Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.81 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.81 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.81 |
| ▸ | PGR | P06401 | 1/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499623 | 0.92 | PDE3B (0.69) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Vesnarinone SCHEMBL29402965 | 0.90 | PDE3B (1.00) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Vesnarinone SCHEMBL6243858 | 0.90 | PDE3B (1.00) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Vesnarinone SCHEMBL50993 | 0.90 | PDE3B (1.00) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL11052649 | 0.89 | NR3C1 (0.71) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL11202820 | 0.85 | NR3C1 (0.78) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Vesnarinone SCHEMBL4221551 | 0.85 | PDE3B (0.89) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Water SCHEMBL11200345 | 0.84 | NR3C1 (0.76) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| Water SCHEMBL11200349 | 0.84 | NR3C1 (0.76) | PDE3BPDE3ANR3C1PGRSLC6A4 | |
| SCHEMBL7269908 | 0.84 | SLC6A4 (0.78) | PDE3BPDE3ANR3C1PGRSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552373-B1 | APOPTOSIS REGULATOR | OTSUKA PHARMA CO LTD (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5658912-A | 6-(4-(3,4-DIMETHOXYBENZOYL)-1-PIPERAZINYL)CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5543412-A | ADMINISTERING A BENZOYL PIPERAZIN QUINOLINS VIRICIDES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0552373-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |