Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28142543 | 0.86 | MAPK1 (0.54) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL30846532 | 0.86 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL29184272 | 0.86 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL7694544 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| Ag1295 SCHEMBL925674 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL8499328 | 0.82 | SMN1; SMN2 (0.72) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL15850501 | 0.80 | TLR9 (0.53) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL30107647 | 0.80 | TLR9 (0.53) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL28165527 | 0.80 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 | |
| SCHEMBL8503044 | 0.80 | MAPT (0.52) | NPC1RAB9ASMN1; SMN2PDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | claimed |