Ag1295

Ag1295

SCHEMBL925674

Cc1cc2ncc(-c3ccccc3)nc2cc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 1.00
RAB9A P51151 3/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
PDGFRB P09619 2/20 1.00
KDR P35968 1/20 1.00
FLT3 P36888 1/20 1.00
ALDH1A1 P00352 1/20 0.68
GLA P06280 1/20 0.68
GAA P10253 1/20 0.68
MAPT P10636 1/20 0.68
HDAC6 Q9UBN7 1/20 0.68
TLR9 Q9NR96 1/20 0.60
PDGFRA P16234 1/20 0.54
NQO2 P16083 1/20 0.50
ADORA3 P0DMS8 1/20 0.49
MAPK1 P28482 1/20 0.49
KDM4E B2RXH2 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14532728 0.89 NPC1 (0.79) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL29184272 0.85 NPC1 (0.74) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL30846532 0.85 NPC1 (0.74) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL6215142 0.85 NPC1 (0.73) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL13541764 0.82 NPC1 (0.70) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL8499222 0.82 NPC1 (0.70) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL16687607 0.82 NPC1 (0.70) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL30846535 0.82 NPC1 (0.70) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL8499923 0.81 SMN1; SMN2 (0.69) NPC1RAB9ASMN1; SMN2PDGFRBKDR
SCHEMBL29351353 0.81 SMN1; SMN2 (1.00) NPC1RAB9ASMN1; SMN2PDGFRBKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260027230-A1 DRUG DELIVERY SYSTEM, TREATMENT KIT, AND METHOD FOR INHIBITING PROLIFERATION OR METASTASIS OF CANCER CELL CHINA MEDICAL UNIVERSITY (TW) 2026-01-29 US claimed
EP-4572781-A2 SYNERGISTIC INTERACTIONS FOR IMPROVED CANCER TREATMENT The United States of America, as Represented By the Secretary, Department of Health and Human Services (US) 2025-06-25 EP claimed
US-20250161293-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT AROG PHARMACEUTICALS, INC. 2025-05-22 US claimed
US-12295948-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment AROG PHARMACEUTICALS, INC. (US) 2025-05-13 US claimed
WO-2024173833-A1 COMBINATION OF A CDK INHIBITOR AND A FLT3 INHIBITOR FOR THE TREATMENT OF CANCER MEI PHARMA, INC. (US) 2024-08-22 WO claimed
US-20240165199-A1 PROX1 PREVENTS MYXOMATOUS VALVE DISEASE BY INHIBITING PDGF-B SIGNALING OKLAHOMA MEDICAL RESEARCH FOUNDATION 2024-05-23 US claimed
US-20240100040-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT AROG PHARMACEUTICALS, INC. 2024-03-28 US claimed
WO-2024040132-A2 SYNERGISTIC INTERACTIONS FOR IMPROVED CANCER TREATMENT THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) 2024-02-22 WO claimed
US-11857546-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment AROG PHARMACEUTICALS, INC. (US) 2024-01-02 US claimed
US-20230128591-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT AROG PHARMACEUTICALS, INC. 2023-04-27 US claimed
WO-2005051229-A2 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME AVANTEC VASCULAR CORPORATION (US) 2005-06-09 WO claimed
US-20050125054-A1 Devices delivering therapeutic agents and methods regarding the same AVANTEC VASCULAR CORPORATION (US) 2005-06-09 US claimed
WO-2004010900-A1 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME AVANTEC VASCULAR CORPORATION (US) 2004-02-05 WO claimed
US-RE36256-E ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-07-20 US claimed
EP-0584222-B1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE POULENC RORER INT (US) 1997-10-08 EP claimed
US-5646153-A INHIBITING ABNORMAL CELL PROLIFERATION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-07-08 US claimed
US-5480883-A Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-01-02 US claimed
EP-0584222-A4 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE POULENC RORER INT (US) 1994-07-06 EP claimed
EP-0584222-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE. RHONE POULENC RORER INT (US) 1994-03-02 EP claimed
WO-1992020642-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027230-A1 DRUG DELIVERY SYSTEM, TREATMENT KIT, AND METHOD FOR INHIBITING PROLIFERATION OR METASTASIS OF CANCER CELL LDLR, NPC1L1, LPXN NPC1 16/4885RAB9A 3226/4885SMN1; SMN2 2481/4885
US-11857546-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment FLT3, RET, MKI67 NPC1 3832/4885RAB9A 2829/4885SMN1; SMN2 3436/4885
US-12295948-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment FLT3, RET, MKI67 NPC1 3832/4885RAB9A 2829/4885SMN1; SMN2 3436/4885
US-20230128591-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT FLT3, RET, MKI67 NPC1 3832/4885RAB9A 2829/4885SMN1; SMN2 3436/4885
US-20250161293-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT FLT3, RET, MKI67 NPC1 3832/4885RAB9A 2829/4885SMN1; SMN2 3436/4885
US-20240100040-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT FLT3, RET, MKI67 NPC1 3832/4885RAB9A 2829/4885SMN1; SMN2 3436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.