Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.74 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502173 | 0.90 | PDGFRB (0.63) | PDGFRBPDGFRABACE1CYP2A6CYP2E1 | |
| SCHEMBL31060213 | 0.86 | PDGFRB (1.00) | PDGFRBPDGFRABACE1CYP2A6CYP2E1 | |
| SCHEMBL30172705 | 0.81 | CYP2A6 (0.56) | PDGFRBPDGFRACYP2A6CYP2E1CYP2B6 | |
| SCHEMBL3238945 | 0.81 | CYP2A6 (0.56) | PDGFRBPDGFRACYP2A6CYP2E1CYP2B6 | |
| SCHEMBL8499498 | 0.77 | PDGFRB (0.65) | PDGFRBPDGFRACYP2A6CYP2E1CYP2B6 | |
| SCHEMBL8501272 | 0.77 | PDGFRB (1.00) | PDGFRBPDGFRABACE1CYP2A6CYP2E1 | |
| SCHEMBL19180724 | 0.76 | PDGFRB (1.00) | PDGFRBPDGFRABACE1CYP2A6CYP2E1 | |
| SCHEMBL9274154 | 0.76 | PDGFRB (0.70) | PDGFRBPDGFRABACE1CYP2A6CYP2E1 | |
| SCHEMBL26549163 | 0.74 | PDGFRB (0.61) | PDGFRBPDGFRAGAK | |
| SCHEMBL26549437 | 0.74 | PDGFRB (0.61) | PDGFRBPDGFRAGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |