Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.65 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060894 | 0.79 | PDGFRB (1.00) | PDGFRBPDGFRACDK8CYP2E1CYP2A6 | |
| SCHEMBL8501434 | 0.79 | PDGFRB (1.00) | PDGFRBPDGFRACDK8CYP2E1CYP2A6 | |
| SCHEMBL8502173 | 0.78 | PDGFRB (0.63) | PDGFRBPDGFRAMAP4K4TOP1CYP2E1 | |
| SCHEMBL8499486 | 0.77 | PDGFRB (0.74) | PDGFRBPDGFRAMAP4K4TOP1CYP2E1 | |
| SCHEMBL3238945 | 0.76 | CYP2A6 (0.56) | PDGFRBPDGFRACYP2E1CYP2A6CYP2B6 | |
| SCHEMBL30172705 | 0.76 | CYP2A6 (0.56) | PDGFRBPDGFRACYP2E1CYP2A6CYP2B6 | |
| SCHEMBL8887276 | 0.74 | CHEK2 (0.53) | MAP4K4MAPK10NT5ESSTR2 | |
| SCHEMBL8503296 | 0.72 | MAP4K4 (0.47) | MAP4K4NT5E | |
| SCHEMBL26259994 | 0.69 | CYP2A6 (0.52) | PDGFRBPDGFRACDK8CYP2E1CYP2A6 | |
| SCHEMBL12074839 | 0.69 | FYN (0.53) | PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |